The old town of Rethymnon is one of the best-preserved towns of the Renaissance. Lying in the heart of modern Rethymnon, it combines the oriental features of the Turkish period with Renaissance-style Venetian architecture.
After the Venetian conquest of Crete (1204), the town of Rethymnon was built according to the rules of Venetian architecture. The original craftsmen were Venetians, but these later were replaced by Cretan murari, Venetian-trained master builders.

The layout of Rethymnon is directly linked to the sea, with the main Venetian street, the Ruga Maistra (today’s coastal Venizelou Avenue) running parallel to the sea. The opposite is true of Heraklion and Hania, where the town is closed to the sea for reasons of defence and the main street is at right angles to the coast.